Principal investigatorDr. Niels de Wind. Three DNA transaction pathways define checkpoint, senescence, apoptosis and mutagenic responses to endogenous or exogenous agents that induce bulky or helix-distorting (‘disruptive’) nucleotide lesions. First, nucleotide excision repair (NER) removes most lesions. Second, Translesion DNA Synthesis (TLS) allows the post-replication of lesions that arrest processive replication.
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DNA efficiently without falling off the template DNA. 10. Dna A- It is a origin binding protein, binds to origin of replication just before initiation of replication. 11. Dna B - Also known as helicase. Helicase unwinds DNA strands using ATP energy and moves processivelly ( i.e ., does not leave the DNA until replication is finished).
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Aug 14, 2001 · The Ter sites specifically interact with the replication terminator protein called Tus, which is a polar contrahelicase, i.e., it impedes the DNA unwinding activity of DnaB in an orientation-dependent manner (5, 6).
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The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and subsequently the partitioning of its cytoplasm and other components into two daughter cells in a process called cell division.
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Journey inside a cell as you follow proteins in Cell Signals. Zoom along a three-dimensional rendering of 650,000 nucleotides of human chromosome in Chromosome 11 Flyover. Processes like DNA translation, transcription, replication, and more are explained in interactive animations.
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First, among the DNA Replication activities, that launches the process is that a nick is formed by DNA gyrase. Unlike the C-G base pairs, the A-T base pairs have only two Hydrogen bonds holding them together; hence the location with an abundance of A-T bases is the ideal spot to crack the double helix with minimum energy required.
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Students reinforce their knowledge that DNA is the genetic material for all living things by modeling it using toothpicks and gumdrops that represent the four biochemicals (adenine, thiamine, guanine, and cytosine) that pair with each other in a specific pattern, making a double helix. Student teams trade DNA "strands" and de-code the genetic sequences to determine the physical characteristics ...
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Paperclip DNA Replication DNA Replication Overview: • To “replicate” DNA means to produce an exact copy of itself. • DNA is able to make an exact replica of itself because of the base pairing characteristics (A with T and C with G). • When DNA makes a duplicate molecule of itself, the two strands unwind.
Dna2 is a protein with both DNA nuclease and helicase activities. It was found to be involved in both DNA replication and repair. In replication, it facilitates Okazaki fragment processing. In DNA repair, it functions during double strand break repair by homologous recombination.
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DNA Paper Model Activity Level: Grade 6-8 Students will be able to: 1. Identify the component molecules of DNA. 2. Construct a model of the DNA double-helix. 3. Identify which bases are found in pairs in the DNA double-helix. 4. Predict the appearance of a complimentary strand of DNA when given half of a double-helix molecule.
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DNA Replication Name _____ Step 1: After you have completed your DNA keychain, label the bases on the paper model with A, T, G, or C and color the squares to match the bases exactly as they are on your keychain from the bottom to the top. Step 2: "Unzip" the paper model by cutting it ...
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The Elg1protein forms an RFC-like complex in charge of unloading PCNA from chromatin during DNA replication and repair. Mutations in the ELG1 gene caused genomic instability in all organisms tested and cancer in mammals. Here we show that Elg1 plays a role in the induction of the DNA damage checkpoint, a cellular response to DNA damage.